• The contribution of local ETA and ETB receptors towards heat

  2019-12-09

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor Brassinolide in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies

• Pulmonary fibroblasts can regulate the wound healing process

  2019-12-09

  

  Pulmonary fibroblasts can regulate the wound healing process by secreting and processing extracellular matrix (ECM), chemokines, and cytokines. However, persistent and atypical fibroblast proliferation can result in ECM accumulation and may trigger the onset or development of pulmonary fibrosis [[17

• br Materials and methods br

  2019-12-09

  

  Materials and methods Results Discussion CHIKV is an important arthropod borne virus with substantial impact on global health and cause a major viral disease that requires the development of antiviral drug to combat chikungunya disease. Virus specific proteases have particularly become an a

• Tumor associated macrophages TAMs one

  2019-12-09

  

  Tumor-associated macrophages (TAMs)—one of the limiting factors in anti-tumor immunity—are associated with the poor clinical outcome in most carcinomas, owing to their potential to promote angiogenesis and local invasion, increase the metastasis of tumor cells, and inhibit the anti-tumor immunity.11

• Accumulated evidence indicates that apelin plays a protectiv

  2019-12-06

  

  Accumulated evidence indicates that apelin plays a protective role in ischemic stroke, contributing to post-stroke recovery (Yang et al., 2014; Chen et al., 2015; Xin et al., 2015; Yan et al., 2015). Apelin gene (APLN) encodes prepro-apelin with 77 amino acids, while the C-terminal 23 Betamethasone

• LY3023414 Introduction Enzymes have higher selectivity speci

  2019-12-06

  

  Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s

• An important role for the precursor molecule

  2019-12-06

  

  An important role for the precursor molecule of the main EBI2 ligand, 25-OHC, in the inhibition of inflammation was recently shown. 25-OHC was demonstrated to inhibit inflammasome induction in mouse macrophages [28]. Inflammasome assemblies are the sites of caspase 1 activation and lead to the gener

• Recent studies have also uncovered additional roles for

  2019-12-06

  

  Recent studies have also uncovered additional roles for E2 enzymes and E2~Ub conjugates in modulating the activity of deubiquitinating enzymes (DUBs), such as OTUB1 (Juang et al., 2012, Wiener et al., 2013, Wiener et al., 2012). Interestingly, OTUB1 has also been shown to associate and modulate the

• Structural homology modelling Intensive Phyre modelling

  2019-12-06

  

  Structural homology modelling. Intensive Phyre2 modelling [44] was performed using the primary amino NG,NG-dimethyl-L-Arginine hydrochloride mg sequence of A1S_0222 as input to generate an atomistic 3D-homology model of A1S_0222. The fit to the SAXS data of the homology model as well as the fit to

• The TELI results of DNA

  2019-12-06

  

  The TELI results of DNA damage responses to CAA and SO then informed our choice of bacterial strains in subsequent experiments. We investigated E. coli cellular survival in response to CAA and SO exposure by determining the sensitivity of a number of E. coli strains, each possessing single or multip

• Previous studies on the chemokines role in

  2019-12-06

  

  Previous studies on the chemokines role in depression are not detailed enough, and cannot sufficiently demonstrate even a hypothetical mechanism explaining the differences in levels of particular chemokines and their receptors, in relation to the severity of depression [29], [30]. Previous studies o

• After incorporation of random nucleotides by TdT

  2019-12-05

  

  After incorporation of random Ciclopirox by TdT during heavy-chain rearrangements, both TdT and pol λ may perform in trans polymerase activity (in unknown proportions), whereas synthesis of the complementary strand can only be achieved by pol λ using its gap-filling activity, which TdT lacks becaus

• br Development of the double strand break

  2019-12-05

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using leukotriene receptor antagonist in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophi

• DGK negatively regulated the extension of long axon neurite

  2019-12-05

  

  DGKδ negatively regulated the extension of long axon/neurite (Fig. 4, Fig. 5, Fig. 6). The results strongly suggest that deficiency of DGKδ induces OCD-like behavior by enhancing axon/neurite outgrowth. DGKδ positively regulates growth factor signaling (Crotty et al., 2006). Therefore, DGKδ deficien

• As previously reported azole class antifungal drugs inhibit

  2019-12-05

  

  As previously reported, azole class antifungal drugs inhibit fungal CYP450 14α-demethylase, as this interrupts the conversion of lanosterol to ergosterol, a component of the fungal cell membrane (Hof, 2006). Furthermore, correlation between fluconazole dose, the extent of hepatic hypertrophy, the le

16124 records 949/1075 page Previous Next First page 上5页 946947948949950 下5页 Last page