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br Bipartite graph br Algorithm for CFC br
2020-03-20
Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in Nevirapine from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-1A pico-sa
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The totality of evidence from randomized clinical
2020-03-18
The totality of evidence from randomized clinical trials supports the premise that worsening Salicylic acid synthesis failure is a class effect of DPP-4 inhibitors. A meta-analysis by Verma et al. (54) of 100 randomized controlled clinical trials reported that the use of DPP-4 inhibitors was accompa
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In the PTEN loss mouse model deletion
2020-03-18
In the PTEN loss mouse model, deletion of ATG7 gene not only caused an autophagy-deficient phenotype, but also postponed the progression of inoculated prostate tumor [22]. On the basis of these experimental facts, these ATG7 and PTEN related genes were then compared with the 3020 BCR-associated gene
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br Introduction The dorsal periaqueductal gray matter dPAG
2020-03-18
Introduction The dorsal periaqueductal gray matter (dPAG) is a midbrain site markedly involved in fear/anxiety-evoked responses as well as in nociception (see, for example, Bandler and Carrive, 1988, Deakin and Graeff, 1991, Fardin et al., 1984a, Fardin et al., 1984b, Litvin et al., 2007). Chemic
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br Clinical studies br Practical implications for young
2020-03-18
Clinical studies Practical implications for young women Conclusion Research on the oncogenic mechanism of hormones has advanced dramatically in the latter years. The finding that progestogens are more powerful determinants of risk than estrogens in breast cancer has been added to advances i
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In our former work our interest
2020-03-18
In our former work, our interest was in discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Along this line, with natural alkaloid taspine as the lead compound, rounds of structure optimization were performed to develop novel VEGFR-2 inhibitors [[13], [14], [15]]. Among them, BPS-7, b
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Another enzyme class that has emerged as a
2020-03-18
Another enzyme class that has emerged as a potential alternative to P450s are the so-called ‘unspecific peroxygenases’ (UPOs). They also contain a heme but are extracellularly expressed fungal enzymes that are often more stable than P450 monooxygenases. Importantly, UPOs use H2O2 instead of O2 as th
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Talabostat mesylate To function as Ub ligases E proteins mus
2020-03-18
To function as Ub-ligases, E3 proteins must interact with E2s. As compared to the extensive studies on E3s, functional studies on E2s are relatively rudimentary in higher plants. We previously reported that there are 48 genes encoding Ub-conjugating (UBC) fold-containing putative E2 proteins in the
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In order to assess quantitatively the contribution of the
2020-03-18
In order to assess quantitatively the contribution of the ung, dug and dut BIBW2992 to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method, which
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microtubule br Acknowledgements br Introduction Chemokines a
2020-03-17
Acknowledgements Introduction Chemokines are a superfamily of chemotactic cytokines that play important roles in regulating cell migration and activation under inflammatory conditions (Nomiyama et al., 2008; Peatman and Liu, 2007; Zlotnik and Yoshie, 2000), such as angiogenesis (Arenberg et al
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A widely accepted mechanism to differentiate hESCs into
2020-03-17
A widely accepted mechanism to differentiate hESCs into cardiomyocytes is through perturbation of the canonical Wnt/β-catenin pathway. Initial Wnt activation is required to form the chem 6 [3]. Thereafter, it is believed that inhibition of the canonical Wnt/β-catenin pathway is pivotal for cardiomy
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bms-690514 The current study showed that the tested nonselec
2020-03-17
The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti
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Social memory is encoded within certain sites but
2020-03-17
Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs. Memorials, such as cemeteries, require some kind of activity by its visitors for their meanings to be activated (Hutchinson, 2009, Winter, 2010). Following Eden
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The two SNPs rs rs presented above are
2020-03-17
The two SNPs rs4818-rs4680 presented above are part of the haploblock (rs6269, rs4633, rs4818, rs4680) presenting the 3 major haplotypes which influence the enzymatic activity of COMT. This activity is inversely related to the sensitivity of pain in a chronic pain syndrome; so the haplotype (GCGG) h
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Due to its several industrial applications the
2020-03-17
Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian ML-099 (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 2003) and
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