• Several studies on the collagen receptor DDR

  2021-01-07

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR tachykinin receptor on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to D

• br Introduction Epithelial mesenchymal transition EMT is a b

  2021-01-07

  

  Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial XMD17-109 lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation during embryo dev

• Intriguingly one E residue may serve

  2021-01-07

  

  Intriguingly, one E2 residue may serve as a molecular ‘gate’ to allow the C-terminus of ubiquitin to access the closed E2~Ub conformations favorable for ubiquitin transfer. This residue, Asp87 in UbcH5 family members, resides on one side of the opening that leads to the active site Cys (Fig. 4D). In

• tetraethylammonium br Materials and methods br Results br Di

  2021-01-07

  

  Materials and methods Results Discussion The incretin hormones potently stimulate insulin secretion, and it is generally assumed that this is mediated by an endocrine mechanism such that GIP and GLP-1 through the circulation reach the islet beta tetraethylammonium to stimulate their secret

• In the past few years we and others

  2021-01-07

  

  In the past few years we and others have reported that GLP-1 may also be secreted by sub-populations of alpha IKK-16 in human pancreatic islets (Marchetti et al., 2012, Ellingsgaard et al., 2011), which could contribute to beta cell function and survival (Marchetti et al., 2012, Ellingsgaard et al.

• In order to gain further insights

  2021-01-07

  

  In order to gain further insights into the role of peptidases in B. xylophilus, four cysteine proteases highly secreted by B. xylophilus (Cardoso et al., 2016) were selected four further characterisation. Materials and methods Results and discussion Structural prediction and analysis The i

• The detection of galactomannan GM a polysaccharide that is

  2021-01-06

  

  The detection of galactomannan (GM), a polysaccharide that is released during Aspergillus growth, is a useful and reliable non-invasive diagnostic test for screening and management of aspergillosis and is often more sensitive than culture (Schelenz et al., 2015, Fisher et al., 2013). The level of ga

• The CPA parameters of SO were

  2021-01-06

  

  The CPA parameters of SO2 were calculated based on Eq. (11) using the vapor pressure and saturated liquid density data of SO2 over the reduced temperature range of 0.55 to 0.9. All of the data used were taken from the NIST database [53]. The resulting CPA parameters of SO2 are presented in Table S1

• euk 134 br Methods and materials br Cyclooxygenase COX is

  2021-01-06

  

  Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic euk 134 to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expressed in many

• The aim of this study was to use molecular methods

  2021-01-06

  

  The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho

• The vascular endothelium is a highly

  2021-01-06

  

  The vascular endothelium is a highly dynamic multifunctional organ that is critically involved in the regulation of vessel integrity, vascular growth and remodeling, tissue growth and metabolism, immune responses, cell adhesion, angiogenesis, hemostasis and vascular permeability [23]. Therefore, the

• Although we observed increases in

  2021-01-06

  

  Although we observed increases in α1-AR mediated cAMP production separately in the nucleus and cytoplasm, compartment specificity was observed for PKA activation. GPCRs and their effector proteins are commonly found in multiprotein signalosomes with A-kinase anchoring proteins (AKAPs) serving as sca

• br Introduction Receptor tyrosine kinases RTKs are criticall

  2021-01-06

  

  Introduction Receptor tyrosine kinases (RTKs) are critically involved in the development and progression of human cancers and are therefore useful targets for anti-cancer therapies [1]. The Eph receptors represent the largest subfamily of receptor protein kinases and interact with ligands called

• The requirement for two distinct signalling pathways

  2021-01-06

  

  The requirement for two distinct signalling pathways for cAMP-induced growth arrest likely represents an important mechanism allowing VSMC to finely modulate their cellular responses to cAMP-elevating stimuli. Our data demonstrates for the first time that activation of both pathways in VSMC results

• br Conclusions br Declaration of interest br

  2021-01-06

  

  Conclusions Declaration of interest Acknowledgment This work was supported by an AIRC (Associazione Italiana Ricerca Cancro-Milan) Grant KFR062-2 to A.G.L, by Ricerca Funds by Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Grant No. 180/01) and by the ERA-NET “ERare” (Grant GO

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