• The use of the periplasmic fraction as starting material and

  2021-01-26

  

  The use of the periplasmic fraction as starting material and the presence of a unique purification step concurred in improving the purification yield to 25.3%, which is significantly higher than what obtained with the previous purification protocol (6.7%). In addition, the analysis of the kinetic co

• br Expression and Tissue Functions of DDRs The DDRs

  2021-01-26

  

  Expression and Tissue Functions of DDRs The DDRs are widely expressed in different tissues, both during development and in adult organisms. DDR1 mRNA is found in many tissues in mice and humans, with high levels in brain, lung, kidney, spleen, and placenta (Di Marco et al., 1993, Johnson et al.,

• Mouse Cyp a is a homologous isoform of the

  2021-01-26

  

  Mouse Cyp3a11 is a homologous isoform of the human CYP3A4 gene, and both are highly expressed in the liver (Hart, Cui, Klaassen, & Zhong, 2009). CYP3A4 is the most abundant CYP450 in hepatic microsomes responsible for drug and xenobiotic metabolism (Zanger & Schwab, 2013), and it is the most active

• br Experimental Procedures br Author Contributions

  2021-01-25

  

  Experimental Procedures Author Contributions Acknowledgments Research in the Davis laboratory was supported by grants 4R37NS019904, 5R01NS052351, and 1R35NS097224 from NINDS. Research in the Martemyanov laboratory was supported by grants DA036596 and DA026405 from NIDA, and MH105482 from NI

• Iberin The involvement of FOXO and STAT in DNA PKcs and

  2021-01-25

  

  The involvement of FOXO3 and STAT5 in DNA-PKcs and Iberin IV has not been reported before, and the search by the ECR browser (http://ecrbrowser.decode.org) revealed that 1kb of the 5′ promoter of DNA-PKcs possesses 4 STAT (−908bp to −901bp, −676bp to −656bp, −533bp to −526bp and −66bp to −59bp) and

• Diacylglycerol kinase was one of the hits identified from

  2021-01-25

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a 1,4-DPCA australia of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61], [62], [63

• bifonazole br Acknowledgments br Introduction Heterocyclic c

  2021-01-25

  

  Acknowledgments Introduction Heterocyclic chemistry has become one of the most important fields of research in pharmaceutical industry due to their many fold applications. Amongst all, heterocyclic bifonazole containing nitrogen and oxygen have shown most potent biological activities. It foll

• br Results This study was carried out with

  2021-01-25

  

  Results This study was carried out with a series of engineered extracellular matrix films of collagen assembled at hydrophobic surfaces, which allow for independent control of supramolecular structure, mechanical stiffness, and receptor recognition sites [17], [21]. Vascular smooth muscle Lomusti

• In addition to the blockade of airway smooth muscle contract

  2021-01-25

  

  In addition to the blockade of airway smooth muscle contractions, CysLT1 receptor antagonists also exerted a potent anti-inflammatory effect at this level. The oral administration of MEN91507, Pranlukast, Montelukast, and Zafirlukast also produced a long-lasting inhibition of leukotriene D4-induced

• We have previously disclosed the discovery

  2021-01-25

  

  We have previously disclosed the discovery of a 7-azaindole-3-acetic 8220 CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of that work, others

• Conversely to the reduction in restraint

  2021-01-25

  

  Conversely to the reduction in restraint-evoked HR increase following the blockade of CRF receptors, Nijsen et al. [28] demonstrated that BNST treatment with a nonselective CRF calculate the concentration antagonist enhanced the tachycardia evoked by contextual fear conditioning. Taken together, th

• In this study new and more

  2021-01-25

  

  In this study, new and more extended tables of parameters were estimated for pure fluids and binary mixtures that are relevant to biodiesel systems. Also, calculations for glyceride systems will be shown, which is a topic not investigated before with the CPA model. As before [21], [22], [23], [24],

• Goel et al reported study of diacetoxy methylcoumarin

  2021-01-25

  

  Goel et al. reported study of 7,8-diacetoxy-4-methylcoumarin (DAMC) 63 and its thiocoumarin derivative 7,8-diacetoxy-4-methylthiocoumarin (DAMTC) for their effect on human non-small cell lung cancer A549 cells. The study suggested that the 7,8-diacetoxy-4-methylcoumarin (DAMC) 63 downregulates Bcl-x

• By using the C elegans

  2021-01-25

  

  By using the C. elegans Matrisome Annotator tool, we found substantial enrichment for matrisome dpp4 in these data sets. Thus, re-analyzing -omic datasets with the C. elegans Matrisome Annotator tool may be useful to generate novel hypotheses about the role of the C. elegans matrisome for various bi

• As the primary model we

  2021-01-25

  

  As the primary model we selected LDL-receptor knockout mice because these resemble the human plasma lipoprotein profile more closely. Currently, genetic models with reduced milk cholesterol content, which mimic cholesterol-free formula feeding, are unavailable. Thus, instead of modifying milk choles

15985 records 729/1066 page Previous Next First page 上5页 726727728729730 下5页 Last page