• NPC L NPC Niemann Pick C

  2021-07-03

  

  NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol Meleagrin from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol-lo

• br Membrane receptor Indirect non genomic signaling As menti

  2021-07-03

  

  Membrane receptor: Indirect non-genomic signaling As mentioned above, not all mitoxantrone responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be acting

• br Steroid biosynthesis br Steroid

  2021-07-03

  

  Steroid biosynthesis Steroid hormone metabolism in breast cancer Conclusion Steroid hormones elicit their biological actions primarily by binding to steroid receptors such as the ER, AR, PR and GR. Although classical breast cancer diagnostic panels assess the expression of the ER and PR, as

• br STAR Methods br Acknowledgments

  2021-07-03

  

  STAR★Methods Acknowledgments We are grateful to Amaia Lujambio, James Fagin, and Ramon Parsons for providing cell lines and Evripidis Gavathiotis for critical reading of the manuscript. We would like to thank Saboor Hekmaty for providing expertise with RNA-seq analysis. P.I.P. would like to ac

• Recent studies have shown that the extracellular regulated p

  2021-07-03

  

  Recent studies have shown that the extracellular regulated protein kinase 1 and 2 (ERK1 and ERK2), commonly referred to collectively as ERK 1/2, are members of the mitogen-activated protein kinase (MAPK) family. This family of kinases transport signals from the surface of the cell to the nucleus, th

• br Sources of funding br

  2021-07-03

  

  Sources of funding Disclosures Acknowledgments Introduction Insulin secretion from pancreatic β cells is a fundamental process to maintain blood glucose homeostasis. During glucose-stimulated insulin secretion, high glucose causes closure of ATP-sensitive K+ channels (KATP channels), sub

• Conventional aromatic radiofluorination via nucleophilic sub

  2021-07-03

  

  Conventional aromatic radiofluorination via nucleophilic substitution requires electron-withdrawing activating group(s) at the ortho or para position to achieve good radiolabeling yield. In the case of CJ-042794 (), the phenoxy substitution para to the fluoro group is considered an electro-donating

• Although the reasons why viral RNA does not bind to

  2021-07-03

  

  Although the reasons why viral RNA does not bind to and activate PKR in WNV-infected cells are not known, some of the known characteristics of flavivirus infections provide possible clues. The viral glasdegib protein forms dimers that associate with ER membranes and viral RNA (Lindenbach et al., 20

• eicosapentaenoic acid br Materials and methods Details on

  2021-07-03

  

  Materials and methods Details on materials and methods can be found in the Supplemental material section. Results Discussion In our experiments we mimicked inflammation by LPS challenge of M0 macrophages. We discovered a strong increase in expression of CH25H and CYP7B1 while CYP27A1 and H

• In addition to through direct regulation of cell differentia

  2021-07-02

  

  In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the

• L-Phenylephrine receptor Acknowledgments br Introduction Var

  2021-07-02

  

  Acknowledgments Introduction Various researches have been made in the field of the treatment of cancer and inflammatory diseases. Different mechanisms are involved in the progression of cellular damage that gives an idea about new drug targets. There are always some efforts to improve efficacy,

• A related cell based approach was used

  2021-07-02

  

  A related, cell-based approach was used to test the functionality of the various HIV Rev fusions, but in a trans-complementation assay using 293T producers transfected with both VSV G and a Rev-deficient HIV reporter vector encoding both FFLUC and bsd (Fig. 2C). As expected, the non-fused, full-leng

• The CPA parameters of SO

  2021-07-02

  

  The CPA parameters of SO2 were calculated based on Eq. (11) using the vapor pressure and saturated liquid density data of SO2 over the reduced temperature range of 0.55 to 0.9. All of the data used were taken from the NIST database [53]. The resulting CPA parameters of SO2 are presented in Table S1

• Dopamine activity in the PFC and striatum may

  2021-07-02

  

  Dopamine activity in the PFC and striatum may be antagonistic, meaning that lower levels of dopamine in the striatum tend to correspond to higher levels of dopamine in the PFC and vice versa (Cools and D'Esposito, 2011; Tunbridge et al., 2006). Human PET studies have reported that dopaminergic PFC f

• Programmed cell death via apoptosis is associated with a

  2021-07-02

  

  Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap

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