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Idelalisib demonstrates a dual mechanism of action by
2019-06-12
Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour gaboxadol by blocking ingress into and promoting egress out of the lymph node into the blood. Release from the protective lymp
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Many of the emerging non vaccine serotypes
2019-06-12
Many of the emerging non-vaccine serotypes in carriage after PCV13 implementation (11A, 15B/C, 15A, 21, 23B, and 35F) show low potential for causing invasive disease, but some—eg, 12F, 22F, 24F, 8, and 9N—have high disease potential. Moreover, in vulnerable populations (eg, immunocompromised people)
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In the case reported by Goldstein et al
2019-06-12
In the case reported by Goldstein et al. [2], a Riata ST lead (St. Jude Medical, Sylmar, CA, USA) was used. The authors did not mention whether the lead was a dual-coil system or not. If the lead was a single-coil system, the possibility of an HV short circuit between the RV coil conductor and the d
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The congruence between BrS and ERS with respect
2019-06-12
The congruence between BrS and ERS with respect to clinical manifestations and response to therapy lends further support to the repolarization hypothesis. Using an experimental model of ERS, Koncz et al. [30]. recently provided evidence in support of the hypothesis that, similar to the mechanism ope
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Participants identified the most important values that shoul
2019-06-12
Participants identified the most important values that filipin should inform the NHHRA, proposing that research topics focus on vulnerable populations, improve the health system of Papua New Guinea, and contribute to decision-making and policy-making (). After research topics were identified for al
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No es xito peque o que bajo
2019-06-12
No es éxito pequeño que “bajo la dirección del maestro Stols” (así indica el colofón del libro) se lograse tal parecido con ellas, pero conviene subrayar que Jusep Torres Campalans no es mera mímesis material de la colección Le goût de notre temps sino también, o ante todo, estructural. El Picasso
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Introduction Tumor metastases of the skeleton
2019-06-11
Introduction Tumor metastases of the skeleton occur in up to 80% of patients in progressed stages of cancer, most commonly in cases of breast, lung, prostate, kydney and thyroid tumors [1,2]. Bone metastases are often associated with pathologic fractures, hypercalcemia and spinal cord compression,
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There was no significant correlation between the
2019-06-11
There was no significant correlation between the tHcy level and RBC folate level; therefore, we used two-way ANOVA to analyze the relative contributions of serum folate, the C677T genotype, and vitamin B12 to variations in tHcy concentrations. Intervention studies in humans taking folate and/or vita
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Arita et al reported that the mechanism of ST
2019-06-11
Arita et al. reported that the mechanism of ST-segment elevation in inferior leads is right coronary artery hypoperfusion due to vasodilation by Bezold–Jarisch-like reflexes that are induced by stimulation of the 5-Azacytidine in the intra-atrial septum during transseptal puncture and extension [3].
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br Do we need complete isolation of
2019-06-11
Do we need complete isolation of all PVs in every patient? Circumferential PVI results in satisfactory outcomes for ablation of paroxysmal AF, and electrical isolation of all PVs is currently a standard approach to the treatment of AF, as recommended by the expert consensus statement [6]. Complet
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De cualquier modo la fecha para
2019-06-10
De cualquier modo, la fecha para votar la propuesta del cuatripartito latinoamericano fue programada para el 16 de mayo de 1949. Tras intensos días de discusión, donde se pudieron observar las claras diferencias existentes también entre los países de América Latina, el balance final fue de 26 votos
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Las l neas le comunican a Felipe que l
2019-06-10
Las líneas le comunican p2y receptor Felipe que él y sus marañones habían determinado salir De lo primero, denuncia la perversidad de la administración, encabezada por el virrey Cañete, “malo, lujurioso, ambicioso tirano”, quien “premió” a los hombres que combatieron la rebelión de Hernández Girón
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br Heart rate turbulence HRT HRT
2019-06-10
Heart rate turbulence (HRT) HRT was introduced by Schidmt in 1999 [11]. It refers to the physiological phenomenon in response to a premature beat. After a ventricular premature contraction (VPC) and a compensatory pause, there is an increase in blood pressure because of the prolonged filling. Ref
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The ability of tumors to progress to
2019-06-10
The ability of tumors to progress to more malignant phenotypes depends on tumor microenvironment. Blood capillaries, made up of endothelial cells, are usually static under physiological conditions but are induced to proliferate by direct exposure to angiogenic factors, for instance, vascular endothe
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br Discussion Zoledronic acid has been approved for
2019-06-10
Discussion Zoledronic Mifepristone has been approved for prevention and treatment of osteoporosis and glucocorticoids-induced osteoporosis, treatment of Paget\'s disease, hypercalcemia, multiple myeloma and bone metastasis. In the particular case of breast cancer, it is recommended as a monthly a
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