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The study by Quentin Vincent and colleagues
2019-07-01
The study by Quentin Vincent and colleagues in makes good use of data collected with the WHO Buruli ulcer forms. Vincent and colleagues exploited and analysed data for 1357 laboratory-confirmed cases of Buruli ulcer during 10 years at the treatment centre in Pobè, Benin, to provide qualitative and q
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br Raising taxes on tobacco is the
2019-07-01
Raising taxes on tobacco is the measure with the “least compliance” worldwide among the set of measures introduced by the WHO to facilitate implementation of its Framework Convention on Tobacco Control programme. In an extended cost-effectiveness analysis, Stéphane Verguet and colleagues (April, 2
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La Brev ssima relaci n de la destruyci n de
2019-07-01
La Brevíssima relación de la destruyción de las Indias de fray Bartolomé de las Casas, fechada el 8 de diciembre de 1542, se publica en el año 1552 (“… fue rogado e importunado que destas postreras pusiesse algunas por brevedad por escrito”). Finalmente es condenada en 1660 por el Tribunal de la Inq
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The combination therapy was exceedingly well
2019-07-01
The combination therapy was exceedingly well tolerated without any side effects to either drug. Remarkably, despite an advanced PV-stage the JAK2V617F allele burden was rapidly lowered from 90% mutated R-115777 at referral to 59% at 6 months, 28% at 10 months and 12% at 16 months of therapy (Fig. 2
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It is noteworthy that even with low tumor burden
2019-06-29
It is noteworthy that, even with low tumor burden in these patients following CR, peak value at CR status is still a useful indicator for OS, both in the whole cohort, and more importantly, in the intermediate-risk subgroup. Slope is mainly determined by tissue vascularization and perfusion, but cap
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br Safety of continuation of warfarin during
2019-06-29
Safety of continuation of warfarin during the perioperative period of pacemaker and defibrillator surgery An increasing body of literature has suggested that pacemaker and defibrillator PKA inhibitor fragment (6-22) amide without cessation of oral anticoagulation is safe and feasible. Goldstein e
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During a mean of months of follow up freedom from
2019-06-29
During a mean of 41±29 months of follow-up, freedom from VT or VF was observed more frequently in the non-inducible group (24 of 30 (75%)) than in the inducible group (9 of 21 (43%), P=0.03). The estimated cumulative freedom from VT or VF was 88%, 83%, 75%, and 55% at the 1-, 2-, 3-, and 5-year foll
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br A tactical change in research and advocacy is
2019-06-29
A tactical change in research and advocacy is needed urgently before mental health services will be made a priority in low-income and middle-income countries. Mental disorders and substance misuse are the greatest contributors to the global burden of disability, with 175·3 million years lost to di
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More than million almost children younger than years
2019-06-29
More than 200 million—almost 40%—children younger than 5 years in developing countries are not fulfilling their developmental potential. In parts of Africa, up to three-quarters of children are victims of physical abuse, and a third of girls and more than 10% of boys are victims of sexual abuse. One
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De manera puntual ambos gobiernos
2019-06-29
De manera puntual, ambos gobiernos dejaron sentadas sus posiciones ante el nuevo proceso bilateral para normalizar sus relaciones. En su alocución del 17 de diciembre de 2014, el general Raúl Castro destacó, entre otras cosas, que desde su elección como presidente de los consejos de Estado y de Mini
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The development in high income countries shows the
2019-06-29
The development in high-income countries shows the possibilities for progress in twin health and survival: Danish twins born between 1870 and 1900 had higher early-life mortality rates than twins born in the late 20th century and contemporary sub-Saharan twins, with about 40% under-6 mortality (doub
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FLAG Peptide Conflicts of interest br Acknowledgments This a
2019-06-29
Conflicts of interest Acknowledgments This article was supported by grants from the Ministry of Science and Technology, Executive Yuan (MOST 103-2314-B-010-043-MY3), and Taipei Veterans General Hospital (V103C-112; V104C-095; and V105C-096). We also appreciate the Clinical Research Core Laborato
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Previous studies have demonstrated localization of
2019-06-29
Previous studies have demonstrated localization of miR-21 staining in stromal Captopril of OSCC associated with the tongue and mouth floor—this might be a useful prognostic predictor. We also observed miR-21 staining in the stromal cells of tumors. However, since multiple lines of evidence indicate
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However despite the strength of the research by Shawar
2019-06-28
However, despite the strength of the research by Shawar and colleagues, any given process tracing case study can always be improved. In relation to this Article, the empirical tracing of causal processes could be strengthened further in future research, in particular by telling us more explicitly wh
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br Discussion Bone marrow fibrosis is
2019-06-28
Discussion Bone marrow fibrosis is known to be associated with hematolymphoid malignancies such as acute leukemia, Hodgkin and non-Hodgkin lymphoma. Among the acute leukemias, marrow fibrosis is most often seen with acute megakaryoblastic leukemia. It is an uncommon finding in APL and till date o
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